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Inhibition <t>of</t> <t>tyrosinase</t> enzyme (%) by <t>Kojic</t> acid ( A ) and UA ( B ) calculated as IC 50 . Values represent the mean ± of three replicates analyzed.
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Inhibition of tyrosinase enzyme (%) by Kojic acid ( A ) and UA ( B ) calculated as IC 50 . Values represent the mean ± of three replicates analyzed.

Journal: Scientific Reports

Article Title: Apple oil as a source of ursolic acid for the treatment of hyperpigmentary disorders with molecular and clinical evaluation

doi: 10.1038/s41598-025-29398-0

Figure Lengend Snippet: Inhibition of tyrosinase enzyme (%) by Kojic acid ( A ) and UA ( B ) calculated as IC 50 . Values represent the mean ± of three replicates analyzed.

Article Snippet: Ursolic acid (purity ≥ 98.5% HPLC), phloridzin (purity ≥ 99% HPLC), kojic acid (purity ≥ 98.5% HPLC), L-tyrosine (purity ≥ 98% HPLC), tyrosinase from mushroom (activity ≥ 1000 U/mg), human melanoma cell lines A375, MTT, TRI-Reagent, and Nanodrop were purchased from Sigma-Aldrich (Milan, Italy).

Techniques: Inhibition